Synthesis and biological evaluation of ferrostatin-based diamide derivatives as new ferroptosis inhibitors. (PubMed, Bioorg Med Chem Lett) - Sep 28, 2024 - "The synthesized compounds were tested for their protective effects against Erastin-induced injury in human vascular endothelial cells (HUVECs)...Remarkably, compound 36 also demonstrated superior stability in both microsomal (human and mouse) and mouse plasma assays. These findings indicated ferroptosis inhibitor 36 as a promising hit for further developing potential therapeutic drug candidates in cardiovascular diseases."
Journal • Cardiovascular
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Cheng-Shi Jiang; Hui Zheng; Juan Zhang; Kai-Ming Wang; Lei-Ying Zheng; Nai-Yu Zhang; Ning Meng
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