Effects on Iron Metabolism and System Xc- /GPX4 Pathway from Hydroquinone Suggest Ferroptosis of Jurkat Cells. (PubMed, Toxics) - Sep 27, 2024 - "We used erastin-treated cells as a positive control and cells treated with HQ combined with deferoxamine mesylate (DFO) and ferrostain-1 (Fer-1)-treated cells as the negative controls. Notably, the activation of TFRC and the inhibition of FTH1 and System Xc- (cystine-glutamate reverse transporter protein) /GPX4 were associated with HQ-induced ferroptosis. These results provide novel insights into how HQ exacerbates haematopoietic cytotoxicity and provide potential targets for the prevention of HQ-induced diseases."
Journal • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • GPX4 • SLC7A11
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Ge Liu; Hong Wang; Nana Liu; Qiang Li; Yipeng Hu
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