The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic adenocarcinoma (AACRPanCa 2024) - Sep 26, 2024 - Abstract #B085; Pres time: Sep 16, 2024; 04:45 PM - 07:00 PM; Location: American Ballroom South; "Two compounds widely used as ferroptosis inducers are erastin, which acts as an inhibitor of cystine import and thereby depletes cellular glutathione, and RSL-3, which inhibits glutathione peroxidase 4. In vivo studies using human and murine PDAC xenograft models confirmed that HIF-2 knockout impaired tumor growth and increased susceptibility to the pro-ferroptotic agent sulfasalazine. Collectively, these data identify a mechanism by which PDAC evades ferroptosis and identifies a possible therapeutic strategy of combining HIF-2 inhibitors with pro-ferroptotic agents in pancreatic cancer."
Fibrosis • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Adenocarcinoma • Pancreatic Cancer • Solid Tumor • GPX4 • HIF1A • KRAS • SLC3A2 • SLC7A11
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Maimon E Hubbi; Catherine Wang; Erin Hollander; Yasir Suhail; Kshitiz; Alexander Muir; Ben Z Stanger; Chi V Dang
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