Connexin43 overexpression promoted ferroptosis and increased myocardial vulnerability to ischemia-reperfusion injury in type 1 diabetic mice. (PubMed, Int J Med Sci) - Sep 23, 2024 - "The beneficial effects of Cx43 gene knock-down was minified or eliminated by Erastin. It is concluded that Cx43 overexpression exacerbates MIRI under diabetic conditions via promoting ferroptosis, while its down-regulation at early state of diabetes is attributable to enhanced myocardial tolerance to MIRI."
Journal • Preclinical • Cardiovascular • Diabetes • Metabolic Disorders • Myocardial Infarction • Myocardial Ischemia • Reperfusion Injury • Type 1 Diabetes Mellitus • GJA1 • GPX4
|
|
Anyuan Zhang; Danyong Liu; Dongcheng Zhou; Jiajia Chen; Jiaqi Zhou; Jiefu Lin; Ronghui Han; Weiyi Xia; Yan Lu; Yin Cai; Yuhui Yang; Yuxin Jiang; Zhengyuan Xia
|