Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels. (PubMed, Oncogenesis) - Sep 13, 2024 - "Conversely, BAP1-mediated suppression of disulfidptosis was largely abrogated when SLC7A11-mediated cystine uptake was inhibited by the knockout of SLC7A11 or erastin treatment...Consistent with these observations, the expression level of BAP1 was also positively correlated with NADPH-related genes in KIRC patients, though the underlying mechanism mediating NADPH regulation remains further investigation. In summary, our results revealed the role of BAP1 in the regulation disulfidptosis and provided new insights into the understanding of disulfidptosis in tumor development."
Journal • Oncology • Targeted Protein Degradation • BAP1 • SLC7A11
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Dongsheng Huang; Jin Wang; Jing Chen; Kangsheng Tu; Kexin Fan; Minglin Wang; Qiuran Xu; Shaobo Wu; Yanan Zhu; Yilei Zhang; Yuhan Chen; Zhengtao Xiao
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