LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac. (PubMed, Epigenomics) - Sep 13, 2024 - "Chromatin immunoprecipitation and RNA immunoprecipitation analysis monitored the correlation among LINC01232, H3K27ac, p300 and ARNTL2. LINC01232 or ARNTL2 knockdown facilitated erastin-induced ferroptosis. The interaction between LINC01232 and p300 resulted in the enhancement of H3K27ac levels at ARNTL2 promoter to promote ARNTL2 transcriptional activity. ARNTL2 overexpression reversed the promoting effect of LINC01232 knockdown on ferroptosis. LINC01232 inhibited the ferroptosis in CRC by epigenetically upregulating the transcriptional activity of ARNTL2."
Journal • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • ARNTL
|
|
Han Liu; Hongkai Fan; Shengwei Zhuang; Zhekun Huang; Zhirong Wu
|