METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer. (PubMed, Biochim Biophys Acta Gen Subj) - Sep 16, 2024 - "FAM230B knockdown favored ferroptosis and increased BTF3 expression, while its overexpression mitigated erastin-induced ferroptosis in GC cells. Additionally, BTF3 overexpression was found to negate miR-27a-5p's ferroptosis-promoting effects in GC cells. Collectively, our study demonstrates that the m6A modification of FAM230B by METTL3 plays a crucial role in promoting GC progression by reducing ferroptosis, through the modulation of the miR-27a-5p/BTF3 axis."
Journal • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • BTF3 • BTN3A2 • METTL3 • MIR27A
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Aiping Yin; Dan Liao; Haohai Huang; Jiale Li; Jinjun Ye; Meicen Pu; Rong Pu; Runchao Li; Xiaokang Wang; Yanting Gong; Yejia Cui; Yufeng Yang; Yuling Deng; Zhen Tian
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