SGK1 contributes to ferroptosis in coronary heart disease through the NEDD4L/NF-κB pathway. (PubMed, J Mol Cell Cardiol) - Sep 9, 2024 - "In vitro, SGK1 knockdown alleviated the Erastin-induced downregulation of SLC7A11, GPX4, GSH, and GSSG, as well as the upregulation of lipid peroxidation, Fe accumulation, and mitochondrial damage in mouse aortic ECs (MAECs)...In conclusion, SGK1 contributes to EC ferroptosis by regulating the NEDD4L-NF-κB pathway. SGK1 could be recognized as a therapeutic target related to ferroptosis in CHD."
Journal • Cardiovascular • Coronary Artery Disease • Heart Failure • Inflammation • Targeted Protein Degradation • GPX4 • KDM5D • RELA • SLC7A11
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Han Tang; Qingfeng Zhou; Yong Peng; Yu Jiang; Zheng Jia
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