AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis. (PubMed, Sci China Life Sci) - Sep 9, 2024 - "Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin...Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D (Act...Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53."
Journal • Lung Cancer • Oncology • Solid Tumor • SETDB1 • SLC7A11
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Bangxiang Xie; Chen Xiong; Hanzhi Dong; Hong Ling; Qian Hao; Xiang Zhou; Yingdan Huang
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