Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway. (PubMed, Int J Gen Med) - Sep 2, 2024 - "Erastin reversed the effects of PHGDH on calcification of HCASMCs. PHGDH overexpression suppresses the calcification level of HCASMCs by inhibiting ferroptosis through the P53/SLC7A11 signaling pathway, suggesting PHGDH as a promising therapeutic target of CAC."
Journal • Cardiovascular • Coronary Artery Disease • BMP2 • GPX4 • PHGDH • SLC7A11

http://www.ncbi.nlm.nih.gov/pubmed/39206267

Dongdong Li; Ge Guan; Wenting Liu; Yuhai Zou

Sep 2, 2024