FBXW7-Mediated Downregulation of GPX4 Aggravates Acute Kidney Injury Following Ischemia‒Reperfusion. (PubMed, Inflammation) - Sep 1, 2024 - "FBXW7 overexpression in control cells exacerbated erastin-induced ferroptosis, and FBXW7 knockdown inhibited ferroptosis in H12R4-treated cells...In conclusion, our results indicated that FBXW7 plays an important role in the development of IR-AKI by promoting ferroptosis through the downregulation of GPX4 expression. This study provides new insight into FBXW7 as a potential target for treating AKI."
Journal • Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease • Reperfusion Injury • Targeted Protein Degradation • FBXW7 • GPX4
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Dong-Wei Guo; Fan Li; Jun Hao; Li-Min Zhang; Song Zhao; Xiao-Meng Liu
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