Improving effect of selenium on spermatogenesis in mice with cyclophosphamide-induced spermatogenic impairment and its underlying mechanism (PubMed, Zhonghua Nan Ke Xue) - Sep 1, 2024 - "Selenium deficiency causes the reduction of the SLC7A11 and GPx4 gene levels, disorder of ferroptosis-related genes and down-regulation of the GPx4 protein expression in the mouse testis and spermatocytes. Selenium can promote the expression of GPx4, up-regulate the level of SLC7A11, and improve spermatogenesis in the testis of the mouse with SI. There are differences between organic SeM and inorganic SeS in regulating the ferroptosis pathway-related genes."
Journal • Preclinical • ACSL4 • FER • GPX4 • PACERR • PTGS2 • SLC7A11
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Fan Xiao; Guan-Xiang Yuan; Jin-Quan Cheng; Pei-Yi Liu; Wen-Jing Cheng
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