Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis. (PubMed, RSC Chem Biol) - Sep 1, 2024 - "We show that replacement of the amide linker of AA147 with a carbamate linker retains NRF2 activation in neuronal cells and improves protection against neurotoxic insults, including glutamate-induced oxytosis and erastin-induced ferroptosis. Moreover, we demonstrate that inclusion of this carbamate linker facilitates identification of next-generation AA147 analogs with improved cellular tolerance and activity in disease-relevant assays."
Journal • ATF6 • KEAP1
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Christian M Cole; Gabriel M Kline; Jeffery W Kelly; Jessica D Rosarda; Meera Pannikkat; Michael J Bollong; Nicole Madrazo; R Luke Wiseman
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