Mechanisms of Cell Death Induced by Erastin in Human Ovarian Tumor Cells. (PubMed, Int J Mol Sci) - Sep 1, 2024 - "Erastin (ER) induces cell death through the formation of reactive oxygen species (ROS), resulting in ferroptosis. Our study indicates that ER-induced ferroptotic cell death may be mediated similarly in both NCI/ADR-RES and OVCAR-8 cells. Additionally, our results indicate that ER is not a substrate of P-gp and that combinations of ER and RSL3 may hold promise as more effective treatment routes for ovarian cancers, including those that are resistant to other current therapeutic agents."
Journal • Tumor cell • Oncology • Ovarian Cancer • Solid Tumor • ABCB1 • CAT • CHAC1 • GPX4 • HMOX1 • KRAS
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Birandra K Sinha; Brian B Silver; Carl D Bortner; Carri Murphy; Erik J Tokar; Shalyn M Brown
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