NOX1-mediated oxidative stress induces chondrocyte ferroptosis by inhibiting the Nrf2/HO-1 pathway. (PubMed, Sci Rep) - Aug 28, 2024 - "We also revealed that ferroptosis was the main mechanism of cartilage destruction caused by the addition of the ferroptosis activator erastin and the ferroptosis inhibitor ferrostatin-1...This study revealed that NOX1-mediated oxidative stress induces chondrocyte ferroptosis by inhibiting the Nrf2/HO-1 pathway. Our findings contribute to revealing the pathogenesis of OA, providing targets for drug design and optimizing the clinical treatment of OA."
Journal • Immunology • Osteoarthritis • Pain • Rheumatology • IL1B • MMP13 • TNFA
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Ke Wang; Keda Yang; Lin Tao; Yan Yang
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