CAR T cells engineered to secrete IFN-κ induce tumor ferroptosis via an IFNAR/STAT1/ACSL4 axis. (PubMed, Cancer Immunol Res) - Aug 27, 2024 - "IFN-κ could enhance the sensitivity of tumor cells to ferroptosis induced by the small molecule compound erastin and the polyunsaturated fatty acid arachidonic acid...Moreover, CAR T cells engineered to express IFN-κ showed increased antitumor efficiency against H460 cells (antigen positive) and H322 cells (antigen negative) both in vitro and in vivo. We conclude that IFN-κ is a potential cytokine that could be harnessed to enhance the antitumor function of CAR T cells by inducing tumor ferroptosis."
CAR T-Cell Therapy • Journal • Oncology • ACSL4 • IFNAR1 • STAT1
|
|
Feng Li; Hui Wang; Shasha Liu; Xuyang Cui; Yajing Peng; Yaoxin Gao; Yi Zhang; Yifan Huang; Yuyu Zhao
|