METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4. (PubMed, Int J Rheum Dis) - Aug 23, 2024 - "METTL14 depletion inhibits ferroptosis and ECM degradation by suppressing GPX4 mRNA m6A modification in injured chondrocytes."
Journal • Immunology • Osteoarthritis • Pain • Rheumatology • GPX4 • IL1B • METTL14

http://www.ncbi.nlm.nih.gov/pubmed/39175261

Dawei Liu; Jun Liu; Liang Ren

Aug 23, 2024