Long-term residence and efficacy of adenovirus-mimetic nanoparticles in renal target tissue. (PubMed, J Drug Target) - Aug 22, 2024 - "In our study, we encapsulated erastin, a ferroptosis-inducing model compound, into adenovirus-mimetic, mesangial cell-targeting nanoparticles, enabling the direct visualisation of biological effects through ferroptosis-dependent histological changes. By intravital microscopy and analysis of histological sections, we were not only able to localise the injected particles over 10 days within the target cells but also to demonstrate biological activity in the renal glomeruli. In conclusion, we have characterised adenovirus-mimetic nanoparticles as a highly suitable drug delivery platform for the treatment of mesangial cell-associated diseases and additionally provided the basis for a potential renal disease model."
Journal • Chronic Kidney Disease • Diabetic Nephropathy • Glomerulonephritis • IgA Nephropathy • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease
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Achim Goepferich; Christian Hugo; Daniel Fleischmann; Florian Gembardt; Hannah Weißbach; Kathrin Schorr; Melanie Walter; Sagor Halder; Vladimir Todorov
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