Melatonin mitigates the lipopolysaccharide-induced myocardial injury in rats by blocking the p53/xCT pathway-mediated ferroptosis. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - Aug 18, 2024 - "Septic rat model was constructed by exposing to lipopolysaccharide (LPS), and treated by MT, Ferrostatin-1 (Fer-1) and Erastin (Era)...Conversely, these influences of MT on the LPS-induced H9c2 cells were reversed by p53 overexpression. MT is proposed to be a promising agent for treating the LPS-induced myocardial injury, as it relieves myocardial injury by hindering the p53/xCT-mediated ferroptosis in the LPS-induced septic rats."
Journal • Preclinical • Infectious Disease • Inflammation • Septic Shock • GPX4 • IL6 • TNFA
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Bo Yang; Caiqin Luo; Lina Zeng; Mingdao Zhang; Wenji Lin; Xin Jing; Yanlan Lv; Yue Li; Zhida Chen
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