From breath to block: Disseminated invasive aspergillosis presenting with pulmonary, ocular, myocardial and cerebral involvement, and high-grade atrioventricular block during acalabrutinib therapy for chronic lymphocytic leukaemia. (PubMed, IDCases) - Sep 16, 2026 - "The patient was treated initially with intravenous liposomal amphotericin B, before transition to oral isavuconazole following multidisciplinary specialist review. He was eventually palliated due to poor predicted prognosis, and subsequently died. This case highlights the importance of recognising disseminated invasive aspergillosis in patients receiving BTK inhibitor therapy, appreciating that ocular involvement commonly represents haematogenous dissemination rather than the primary site of infection, and considering early multidisciplinary assessment with prompt antifungal therapy when cardiac or central nervous system involvement is suspected."
Journal • Chronic Lymphocytic Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Ocular Inflammation • Oncology • Ophthalmology • Pulmonary Disease • Respiratory Diseases • Uveitis
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Arthur Brook Young; David Knight; Sarah Birkby; Stephen Leslie
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