HIF-PH Inhibitor Promotes Stabilization of HIF-1α via Inhibition of Its Degradation and Exerts Chondroprotective Effects in a Rat Osteoarthritis Model. (PubMed, Int J Mol Sci) - Sep 16, 2026 - "These findings demonstrate that Roxadustat promotes anabolic responses in chondrocytes through stabilization of HIF-1α and suppresses cartilage degeneration in OA. Intra-articular administration of HIF-PH inhibitors may represent a novel disease-modifying therapeutic strategy for OA."
Journal • Preclinical • Hematological Disorders • Immunology • Osteoarthritis • Pain • Rheumatology • ACAN • HIF1A • SOX9 • YBX1
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Atsuo Inoue; Kei Nakamura; Keisuke Sugie; Kenji Takahashi; Kentaro Hayashi; Osam Mazda; Ryota Cha; Shuji Nakagawa; Tomoki Saito; Tsunao Kishida; Yuji Arai; Yuta Fujii
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