Efficacy and Safety of Linaclotide in Pediatric Patients of Functional Constipation: A Meta-analysis of Randomized Controlled Trials. (PubMed, Ann Pharmacother) - Sep 5, 2026 - "Linaclotide improves stool consistency and reduces straining in pediatric FC but does not consistently improve bowel frequency or global symptom resolution. Its safety profile is generally acceptable, although diarrhea is a notable adverse effect. Further long-term, independently funded trials are needed to define its optimal role in clinical practice."
Journal • Retrospective data • Review • Constipation • Gastroenterology • Gastrointestinal Disorder • Pain • Pediatrics
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Devya Khaim Chandani; Erum Siddiqui; Hafiz Waqas Naseer; Humayou Ahmed; Maliha Khalid; Muhammad Saad Khan; Muhammad Tarish Abro
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