Activase (alteplase) - Roche, Boehringer Ingelheim, Kyowa Kirin, Tanabe Pharma
Acute Mechanical Mitral Valve Thrombosis Treated by Endovascular Recombinant Tissue Plasminogen Activator in a 2-Year-Old. (PubMed, JACC Case Rep) - Sep 25, 2026 - "Catheter-directed, continuous low-dose alteplase can promptly restore prosthetic mitral valve function in stable pediatric patients, provided strict monitoring and anticoagulation stewardship." 
Journal • Cardiovascular • Hematological Disorders • Pediatrics • Thrombosis
http://www.ncbi.nlm.nih.gov/pubmed/42782234
 
A Van Damme; G De Beco; J Hubrechts; M Balcaen; M de Thomaz de Bossierre; M Roggen
 
Sep 25, 2026
 
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