CCL7-CCR3 signaling mediates olfactory dysfunction in a mouse model of allergic rhinitis. (PubMed, Front Immunol) - Aug 26, 2026 - "The therapeutic efficacy of intranasal CCL7 inhibition was assessed using Bindarit over a sustained intervention period...In vitro, allergen-stimulated nasal epithelial cells secreted CCL7 that activated microglial cells through CCR3, an effect partially reversed by CCR3 antagonist. The CCL7-CCR3 signaling axis links nasal allergic inflammation to OB microglial neuroinflammation and consequent OD in AR, identifying a promising therapeutic target for AR-associated OD."
Journal • Preclinical • Allergic Rhinitis • Immunology • Inflammation • CCL7 • CCR3
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Chao Ren; Hanrui Wang; Hui Shen; Ting Yang; Tingting Zhao; Xiaoyu Song; Xicheng Song; Yakui Mou; Yao Wang; Yue Hu; Yujiao Chen
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