Targeting conformational flexibility of a reactive intermediate to enhance selectivity of a GABA aminotransferase inactivator (ACS-Fall 2026) - Aug 24, 2026 - Abstract #4512352; Pres time: Aug 26, 2026; 11:40 AM - 12:00 PM; Location: S105d (McCormick Place Convention Center); "Our strategy in this study, targeting dynamics of a reactive intermediate based on a precise mechanistic understanding, serves as a general design principle for fine-tuning the selectivity of MBIs, particularly for other aminotransferases. Mechanism of hOAT inactivation by CPP-115 and enhanced selectivity by (S)-MeCPP-115 Design strategy and enzyme inactivation activity of (S)-MeCPP-115 (5)."
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Koon Mook Kang; Abigail L. Vargas; Luana Assis Ferreira; Benjamin James Des Soye; Mary Corrigan; Cathy Kexin Zhang; Feng Wang; Dorothy Duan; Neil Kelleher; Andrea G. Hohmann; Dali Liu; Richard Silverman
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