Sustained seizure reduction, treatment simplification, and high retention with cenobamate: A 12-month real-world study in refractory and ultra-refractory focal epilepsy. (PubMed, Epilepsia Open) - Aug 6, 2026 - "In this real-world cohort of adults with drug-resistant focal epilepsy, CNB was associated with sustained seizure reduction, high 12-month retention rate, and acceptable tolerability, while most patients were maintained on a low concomitant ASM burden during follow-up. Improvement was observed even in highly treatment-experienced patients, although outcomes were more favorable in those with lower prior ASM burden, supporting the hypothesis that earlier CNB positioning may provide greater efficacy."
Journal • Real-world evidence • CNS Disorders • Epilepsy • Otorhinolaryngology • Vertigo
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Antonella Liantonio; Carmela Pia Ferro; Cosimo Damiano Altomare; Elena Conte; Francesca Cutropia; Giuseppe d'Orsi; Giuseppe Miscio; Maria Teresa Di Claudio; Marta Robustella; Massimo Carella; Nicola Amoroso; Orazio Nicolotti; Paola Imbrici; Umberto Costantino
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