Prednisone, not vamorolone, suppresses novel serum bone and cartilage biomarkers associated with growth failure in children with Duchenne muscular dystrophy. (PubMed, Sci Rep) - Aug 5, 2026 - P2b | "Our clinical trial studies suggest that the 10 novel, corticosteroid-related biomarkers likely reflect the induction of apoptosis in terminal hypertrophic chondrocytes and osteoblasts by traditional corticosteroids. Vamorolone may spare chondrocytes and osteoblasts from this apoptosis, consistent with maintenance of normal growth in vamorolone-treated children.Trial registration The clinical trial registration (clinicaltrials.gov) is NCT03439670 ( https://www.clinicaltrials.gov/study/NCT03439670 )."
Biomarker • Clinical • Journal • Duchenne Muscular Dystrophy • Genetic Disorders • Muscular Dystrophy • ACAN • COL1A2 • COL2A1 • COL6A1
|
|
Eric P Hoffman; Jesse Damsker; Karl Heinz Konopka; Laura Hagerty; Leanne M Ward; Michael Ziemba; Michela Guglieri; Paula R Clemens; Raoul Rooman; Rebecca A Tobin; Utkarsh J Dang; Yetrib Hathout
|