Roles of CCL2 in peri-implantitis and its potential as a treatment target: An animal study. (PubMed, J Periodontol) - Jul 30, 2026 - "Peri-implantitis, an inflammatory condition that impacts the longevity of dental implants, poses considerable challenges due to the limited effectiveness of current treatment methods. This study aimed to understand the role of CC-chemokine ligand 2 (CCL2) in this condition. In our study, CCL2 was discovered to be the primary ligand of CC-chemokine receptor 2 in peri-implantitis. Lab tests using a mouse model revealed that in the absence of CCL2, inflammation and bone loss were reduced. Furthermore, this study confirmed the effect of a drug called bindarit, which inhibits CCL2, in treating experimental peri-implantitis. Investigating the specific roles of CCL2 and assessing the potential benefits of bindarit in managing peri-implantitis provide a scientific foundation for exploring new treatment strategies."
IO biomarker • Journal • Inflammation • Mucositis • Osteoporosis • CCL2 • IL1B • IL6 • ITGAM • PTPRC • TNFA • TRAP
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Anqi Zhou; Ning Li; Qingqing Li; Shasha Yuan; Ting Yang; Wenjie Hu; Wenting Jiang; Xuekang Wang; Yaqian Mo; Ying Wang; Yiping Wei; Zhanming Song; Zhaohuai Zhang; Zhongtian Liu
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