Effect of Concomitant Medications on Adverse Event Frequency, Severity, and Time to Resolution in a Cenobamate Open-Label Trial. (PubMed, Eur J Neurol) - Jul 25, 2026 - "Patients taking fewer concomitant ASMs reported better tolerability as evidenced by fewer and less severe AEs and faster time to resolution. These findings emphasize the importance of optimizing concomitant ASM regimens through dose adjustments, ASM substitution, and treatment simplification to improve tolerability."
Adverse events • Journal • CNS Disorders • Epilepsy • Fatigue • Pain
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Antonio Gil-Nagel; Bernhard J Steinhoff; Elena Alvarez-Baron; John Paul Leach; Karthinathan Thangavelu; Vicente Villanueva; Yaroslav Winter
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