Fibro-Adipogenic Progenitor Ablation Triggers Muscle Atrophy Through Cell Death-Induced Inflammation. (PubMed, J Cachexia Sarcopenia Muscle) - Oct 1, 2026 - "Our findings demonstrate that FAP deletion results in simple muscle atrophy without affecting muscular contractile properties and NMJ function. The atrophy induced by the loss of FAPs occurs through an inflammation-mediated, Cxcl1/2-dependent mechanism, caused by the response to FAP cell death potentially coupled with the absence of FAP actions on the inflammatory environment."
Journal • Inflammation • Muscular Atrophy • CCL2 • CXCL1 • CXCR2 • FBXO32 • PDGFRA • SQSTM1
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Elisabeth R Barton; Lan Wei-LaPierre; Rachel Y Young; Yangyi E Luo; Young Il Lee; Zoe Abe-Teh
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