Optical electrophysiology for in vitro investigations of neuronal excitability in chronic pain research (Neuroscience 2026) - Sep 27, 2026 - Abstract #PSTR055.21 / Z7; Pres time: Nov 15, 2026; 08:00 AM - 12:00 PM; Location: WCC Halls A-C; "IC50 determinations for e.g. suzetrigine, ziconotide, and gabapentin fell within the expected range. Further, the ability to apply single cell analysis while maintaining a relatively high capacity also indicates that it is highly suitable for mechanistic studies where subtle, modulatory effects need to be determined. The single cell analysis capability is also cell-sparing, which opens for the functional study of DRGs from different species where the access to cells is more limited, such as humans."
Preclinical • CNS Disorders • Pain
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P. KARILA; J. SJÖHOLM; A. SKILJE; L. T. AGHOLME; L. MOLL; J. PIHL
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