A Validated hNav1.9 Screening Cascade for Pain Discovery (Neuroscience 2026) - Sep 27, 2026 - Abstract #PSTR122.06 / J2; Pres time: Nov 16, 2026; 08:00 AM - 12:00 PM; Location: WCC Halls A-C; "Calculated IC₅₀ values (µM) were as follows: A-803467 (3.51), amitriptyline (18.0), ICA-121431 (>30), lidocaine (460), TC-N 1752 (0.2), tetracaine (11.5), tetrodotoxin, TTX (18.7), and VX-548 (14.1). Multiple Nav1.9 screening campaigns have been successfully completed, identifying novel chemical matter. Collectively, these assays constitute a fully validated Nav1.9 screening cascade to support Nav1.9 discovery programmes."
CNS Disorders • Pain • NAV1
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A. M. RUSH; G. D. SMITH; K. L. PUDDEFOOT; S. TOKAR; A. S. HAWORTH; C. M. HODGSON; T. D. M. HILL; A. JINAT; E. B. STEVENS; G. S. CLARK
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