Functional and Compositional Shifts in Lung and Gut Microbiota after One Year of Treatment with Highly Effective CFTR Modulators in Cystic Fibrosis. (PubMed, Arch Bronconeumol) - Sep 26, 2026 - "ETI is associated with minimal compositional but substantial functional reprogramming in CF microbiota. These changes are accompanied by an increase in butyrate-producing taxa, attenuation of host pro-inflammatory pathways, and a shift in lung metabolism toward oxidation. Despite ongoing pathogenic colonization, these changes suggest CFTR modulation is associated with a less inflammatory, more stable host-microbiota ecosystem."
Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases
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Ana Moreno-Blanco; Anita C Schürch; Antonio Oliver; Carmen García-Durán; Concha Gil; Do?ukan Bayraktar; Esther Palacios; Janetta Top; Jesús Oteo-Iglesias; Juan de Dios Caballero; Luis Máiz; Maria Garriga; Natalia Bastón-Paz; Rafael Cantón; Rosa Del Campo; Saioa Vicente-Santamaría
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