Potent Caspase-1 Antagonists From Dihydropyridine Derivatives: In Vitro Fluorescence Assays and Cell Imaging. (PubMed, ChemMedChem) - Sep 21, 2026 - "THD, which exhibited comparable potency to the well-known inhibitor VX-765 (3.68 nM), was selected for further investigation...Western blot analysis of PMA-differentiated THP-1 cells further supported this observation by showing reduced cleaved IL-1β levels in the presence of THD. This inhibitory effect of THD on caspase-1 activity in a complex cell system was further confirmed by the concentration-dependent morphological changes in BMDMs."
Journal • Preclinical • Inflammation • CASP1 • IL1B
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Anawat Ajavakom; Chanakan Tongsook; Islah Muttaqin; Kavisara Srithadindang; Kittiporn Nakprasit; Mongkol Sukwattanasinitt; Pattraporn Chobpradit; Rachanon Eakprachasin; Sucharat Sanongkiet; Tanapat Palaga; Thanapon Charoenwongpaiboon; Thitiporn Pattarakankul; Waroton Paisuwan
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