Trikafta (elexacaftor/tezacaftor/ivacaftor) - Vertex
Thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor. (PubMed, Exp Physiol) - Sep 13, 2026 - "Together with survey insights, this suggests ETI may reduce previous heat-related vulnerabilities and better prepare pwCF for exercise in hot conditions. Updated evidence is needed to refine salt-replacement and hydration strategies, modernise clinical guidance, and support safe physical activity in a warming climate." 
Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Pulmonary Disease • Respiratory Diseases
http://www.ncbi.nlm.nih.gov/pubmed/42731120
 
Anthony I Shepherd; Don S Urquhart; Gary Connett; Heather Massey; Jo Corbett; Julian Legg; Lauren J Clayton; Mark Allenby; Neil Maxwell; Thomas Daniels; Zoe L Saynor
 
Sep 13, 2026
 
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