CFTR modulation alter pancreatic cancer cell growth and signaling: implications for cancer risk in cystic fibrosis. (PubMed, J Cyst Fibros) - Sep 13, 2026 - "CFTR restoration not only improves channel function but also reprograms transcriptional networks to act as a synchronized brake on epithelial replication velocity and migration. These findings suggest that CFTR-targeting therapies may fundamentally influence pancreatic cancer biology and have implications for cancer risk management in PwCF."
Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Pulmonary Disease • Respiratory Diseases • Solid Tumor • CFTR
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Aliye Uc; Andrew W Norris; Anna J Prouty; Carlos H F Chan; Henry Keen; Ian M Thornell; Prabhat Goswami; Yunxia O'Malley; Zachary Campbell
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