Next-Generation CFTR Modulators Control Multiple Mechanisms in Improving the Pathophysiology in ADPKD (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #SA-PO0136; Pres time: Oct 24, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Methods The aim of this study was to examine the therapeutic effect of the CFTR modulators VX809, VX661, and VX445 in Pkd1 R3277C mouse model treated every other day for 3 months. Conclusion These findings support the idea that correction of CFTR post translational modification and trafficking can improve the cystic phenotype in RC mice. Next generation of CFTR modulators show potential as therapeutic agents in ADPKD."
Autosomal Dominant Polycystic Kidney Disease • Nephrology • Polycystic Kidney Disease • Renal Disease • PKD1 • PRKD1 • SLC9A3R2
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Masoud Afshani; Abhishek Sharma; Tanvi Sharma; William B. Guggino; Liudmila Cebotaru
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