MET-1, the active metabolite of erdosteine, enhances antibiotic activity against Pseudomonas aeruginosa in vitro. (ERS 2026) - May 30, 2026 - Abstract #PA4086; Pres time: Sep 7, 2026; 12:30 PM - 02:00 PM; Location: PS-33; Board Number: 8; "Table 1 Reduction in TOB IC50 when combined with 10mg/L MET-1 Metabolic activity Biofilm Biomass 24h 48h 24h 48h RP73 P<0.05 P<0.05 P<0.0001 PA01 P<0.001 P<0.0001 10 days post-infection with RP73, 40mg/kg TOB + 100mg/kg ERD showed a trend in reducing incidence of chronic colonization compared to TOB alone. Conclusion MET-1 significantly potentiated TOB activity versus planktonic and biofilm cultures of P.a. Preliminary in vivo data demonstrated trends for reduced incidence of colonization following combination therapy."
Preclinical • Infectious Disease • Respiratory Diseases
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B. Ramsden; C. Page; R. Amison
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