LARC-GAPs: emerging whole-sporozoite vaccines for high-level sterile protection against malaria. (PubMed, Trends Parasitol) - Oct 7, 2026 - "Despite the recent deployment of the RTS,S/AS01 and R21/Matrix-M vaccines, malaria cases and deaths continue to increase...Recent studies have shown that late liver-stage-arresting, replication-competent (LARC)-GAPs elicit broader immune responses and provide better protection than other malaria vaccines. Here, we highlight the development of GAP vaccines, compare early-arresting GAPs and LARC-GAPs, discuss recent clinical data, and assess their translational potential as next-generation malaria vaccines."
Journal • Review • Infectious Disease • Malaria
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Indrani Chakraborty; Plabita Paul; Raksha Devi; Satish Mishra
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