Immune checkpoint inhibition enhances memory T-cell responses to CEF(T), SARS-CoV-2 spike proteins and ChAdOx1 nCoV-19. (PubMed, Hum Vaccin Immunother) - Oct 7, 2026 - "In line with the anticipated effects of the primary pharmacology of immune checkpoint inhibitors, we outline an acute increase in proliferation and cytokine and cytolytic molecule secretion following immune checkpoint blockade in response to CEF(T), wild-type SARS-CoV-2 spike pools 1 and 2, and ChAdOx1 nCoV-19. Future studies are needed to evaluate the clinical correlates of the veracity of such responses with protection and incidence of adverse events."
Checkpoint inhibition • Journal • Infectious Disease • Novel Coronavirus Disease • Oncology • Respiratory Diseases
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Anna Olsson-Brown; Daniel F Carr; Dean J Naisbitt; Joshua Gardner; Lance Turtle; Lonnie MacDonald; Luisa Hering; Paul Thomson; Sean Hammond; Sophie Grice; Stacey Collins
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