BMP2-Binding Caffeoylquinic Acids from Periploca forrestii Promote Osteoblast Differentiation via Smad Signaling Activation. (PubMed, Biology (Basel)) - Aug 28, 2026 - "Six caffeoylquinic acid derivatives, namely neochlorogenic acid (NCA), 3-O-caffeoyl-4-O-sinapoylquinic acid, chlorogenic acid (CA), cryptochlorogenic acid (CCA), isochlorogenic acid B (IB), and isochlorogenic acid C (IC), were captured as direct BMP2-binding ligands...In an LPS-induced inflammatory model, IB significantly reversed the downregulation of key proteins in the BMP2-Smad pathway (p-Smad1, Smad4, and Runx2) and osteogenic marker genes (Osterix, COL1A1, and OCN), demonstrating its capacity to restore osteogenic function under compromised conditions. Collectively, these findings establish that caffeoylquinic acid derivatives, particularly IB, function as BMP2-targeting osteogenic constituents of P. forrestii that activate BMP2-Smad signaling to promote osteoblast differentiation, thereby offering a pharmacological basis for the development of natural product-derived osteogenic agents."
Journal • BMP2 • COL1A1 • RUNX2 • SMAD4
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Chang Liu; Minghong Dong; Tingting Feng; Xinyue Wang; Xiongwei Liu; Ying Zhou
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