A dual-responsive nanosystem for synergistic antibacterial therapy and inflammatory microenvironment modulation in infected diabetic wound healing. (PubMed, Biomater Sci) - Aug 12, 2026 - "A mesoporous polydopamine (MPDA) core was loaded with chlorogenic acid (CGA), a natural antioxidant, and further coated with a copper-zinc bimetallic organic framework (Cu/Zn-MOF) to fabricate Cu/Zn-MOF@CGA@MPDA NPs, exhibiting pH-responsive dissociation in the acidic infected wound microenvironment...Histological and hematological tests verified its good biocompatibility and biosafety. This work developed a synergistic single-platform strategy for precise regulation of diabetic wound microenvironments, providing a promising therapeutic alternative for refractory diabetic wound treatment."
Journal • Hematological Disorders • Immunology • Infectious Disease
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Furong Chen; Hongwei Xiong; Kaiyong Cai; Miaomiao Tian; Peng Liu; Shaopeng Liu; XinYue Zhang; Yi Wu; Zixuan Wang
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