Feiwei Heji Enhances Antitumor Immunity by MLL4-Dependent Regulation of Pyroptosis in Lung Cancer. (PubMed, Cancer Sci) - Aug 1, 2026 - "HPLC analysis showed that FWHJ primarily contains naringin, chlorogenic acid, amygdalin, and harpagoside...Mechanistically, FWHJ significantly downregulated MLL4 expression, and MLL4 overexpression largely attenuated its antitumor and immune-enhancing effects. These findings suggest that FWHJ suppresses lung cancer progression by downregulating MLL4, activating pyroptosis, and promoting immune cell infiltration, highlighting that MLL4 may serve as a key regulator mediating the antitumor effects of FWHJ."
Journal • Lung Cancer • Oncology • Solid Tumor • CASP1 • CD4 • CD8 • IFNB1 • IFNG • IL1B • KMT2D • NLRP3
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Chufeng Zhang; Nan Cheng; Qiao Peng; Ruoyu Jiang; Tong Zhao; Wei Li; Wenjie Huang
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