Innovative Test Strip-Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves. (PubMed, Adv Sci (Weinh)) - Jul 30, 2026 - "Applying this strategy, from Lycium barbarum leaves, we identified three potent inhibitors: chlorogenic acid, N-acetyl-N'-caffeoylputrescine (NANCP), and N-caffeoylputrescine (NCP), with IC50 ranging from 55.7 to 143.2 µm...Mechanistically, NCP modulated glycerophospholipid metabolism, reshaped gut microbiota, and targeted the proteasome-autophagy pathway, revealing a multi-faceted synergistic mechanism. The research offers a new screening tool for AChE inhibitors and highlights a promising natural multi-target candidate, NCP, for AD therapy."
Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Metabolic Disorders • Pain • IL1B • IL6 • TNFA
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Fen Ma; Gidion Wilson Mening'oo; Guoning Chen; Hui Yuan; Jingui Ma; Lingling Yang; Mei Wang; Weibiao Wang; Weiman Zhang; Xueqin Ma; Yuping Sa; Zhigang Yang
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