Jiuwei Xiaozhi Decoction Alleviates High-Fat Diet-Induced MASLD by Suppressing Hepatic SREBP2-Driven Cholesterogenesis and Restoring PPARα-Mediated Fatty Acid Oxidation. (PubMed, Chem Biol Drug Des) - Jul 30, 2026 - "Molecular docking provided supportive evidence for potential interactions between representative JWXZ constituents and key regulators, including naringin-HMGCR, chlorogenic acid-SQLE, rhoifolin-PPARα, and rhoifolin-SREBP2. These findings suggest that JWXZ ameliorates HFD-induced MASLD mainly by rebalancing hepatic lipid metabolism through coordinated suppression of SREBP2-mediated cholesterogenesis and restoration of PPARα-mediated fatty acid oxidation, with associated attenuation of EGFR-linked inflammatory responses."
Journal • Dyslipidemia • Hepatology • Inflammation • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • CPT1A • EGFR • IL1B • IL6 • PPARA • SQLE • TNFA
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Fangli Li; Ji Wang; Lingru Li; Xinrui Gao; Youcheng Ma; Zhen Huang
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