Effects of Ilex aquifolium Polyphenols on Cardiovascular, Renal and Liver Structure in a Rat Model of Metabolic Syndrome: A Biochemical and Histological Study. (PubMed, Molecules) - Jul 29, 2026 - "The fraction was dominated by chlorogenic acid (59.33 mg/g), neochlorogenic acid (35.39 mg/g), and rutin (9.23 mg/g)...In conclusion, the polyphenol-rich fraction from Ilex aquifolium exerts potent antioxidant and anti-inflammatory effects that translate into substantial cardioprotection in obese Zucker rats. Nevertheless, its capacity to worsen renal injury and hepatic steatosis highlights the need for caution and further dose- and duration-dependent studies before considering therapeutic application in metabolic syndrome."
Journal • Preclinical • Cardiomyopathy • Cardiovascular • Hepatology • Inflammation • Liver Failure • Metabolic Disorders • Nephrology • Obesity • Renal Disease • IL6
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Antoni Szumny; Krystyna Pogoda-Sewrniak; Natalia Pachura-Hanusek; Piotr Kuropka; Renata Nowaczyk
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