Cathepsin B-Oriented Screening, Isolation, and Antitumor Validation of Bioactive Metabolites from Sargassum polycystum. (PubMed, Mar Drugs) - Jul 28, 2026 - "Seven CTSB-binding metabolites were characterized, including chlorogenic acid, caffeic acid, cynarin, loliolide, taxifolin, senkyunolide H, and dihydroactinidiolide, with binding degrees of 73.99-85.61% at 2.5 U/mL CTSB...This effect was associated with reduced CTSB, Ki-67, and Bcl-2 staining, increased Bax staining, enhanced apoptosis, and ultrastructural alterations in tumor tissues. Overall, this study provides a practical CTSB-oriented workflow for discovering antitumor metabolites from marine medicinal algae and supports further investigation of S. polycystum as a potential source of anti-NSCLC candidates."
Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • BCL2 • CTSB
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Congyao Qin; Erwei Hao; Jiagang Deng; Jinhua Lu; Kai Yu; Lingqiu Zhang; Minmin Qin; Wanchao Hou; Xiaotao Hou; Xiuqing Xu; Zhengcai Du
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