Geometrical isomerization of hydroxycinnamic acid under UV-light: Structural plasticity as a driver of metabolite complexity. (PubMed, Photochem Photobiol) - Jul 5, 2026 - "Hydroxycinnamic acid (HCA)-containing molecules such as chlorogenic acids undergo trans/cis isomerization under UV light, a process expected to intensify with increasing sunlight exposure under climate change...DFT modeling of selected cinnamic acid-containing molecules showed that successful isomerization depends on the co-localization of the HOMO and LUMO within the same structural moiety, particularly around the olefinic functional group of the cinnamic acid unit. Most importantly, this study demonstrates that HCAs are versatile molecules that exhibit structural plasticity under UV light by producing cis isomers whose biological consequences remain unexplored."
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Lutendo Michael Mathomu; Mailane Rose Sekgobela; Mwadham Mwombeki Kabanda; Nakisani Babra Moyo; Ntakadzeni Edwin Madala; Rudzani Nemadzhilili
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