Preclinical evaluation of a bioartificial kidney loaded with functional renal tubular cells in a Bama miniature pig model of acute renal failure. (PubMed, Burns Trauma) - Jul 3, 2026 - "Second, we fabricated a cell-supporting interface [chlorogenic acid/poly-L-lysine-modified pristine nanofibrous membrane (CA/PLL-PNF)] with antioxidant properties and enhanced hemocompatibility via the layer-by-layer self-assembly of PLL and CA onto polyacrylonitrile nanofibrous membranes...This study established a renal support platform that integrates viable cells and functional materials. The device exhibited multidimensional biological efficacy in toxin clearance and internal homeostasis regulation and achieved stable extracorporeal circulation in a preclinical large animal model, which provides experimental evidence for advanced organ support strategies in the setting of severe AKI."
Journal • Preclinical • Acute Kidney Injury • Inflammation • Nephrology • Renal Disease • B2M
|
|
Chuyue Zhang; Guangrui Geng; Mengfei Li; Qinggang Li; Shaoyuan Cui; Tianyi Yang; Xiang Li; Xiangmei Chen; Xiaoxiao Liu; Xu Wang; Yiyu Huang; Yunming Xiao
|