Fraction-Dependent Polyphenolic Profile and Biological Activities of Juniperus communis Pseudo-Fruit Extracts: Antioxidant, Antimicrobial and Selective Antimelanoma Effects. (PubMed, Antioxidants (Basel)) - Jun 27, 2026 - "The ethyl acetate-soluble fraction showed the highest polyphenol content (361.08 ± 17.72 mg chlorogenic acid equivalents/g extract) and was enriched in hyperoside, whereas the n-butanol-soluble fraction contained lower phenolic levels and higher rutoside content; both fractions exhibited antioxidant activity correlated with phenolic content and weak-to-moderate antimicrobial activity, particularly against Streptococcus pyogenes. Cytotoxicity assays revealed a dose-dependent antiproliferative effect, with the ethyl acetate fraction displaying higher activity and greater selectivity toward melanoma cells, confirmed by apoptosis-related morphological changes. These findings demonstrate that solvent polarity plays a critical role in enriching bioactive phytochemicals and support the potential of J. communis fractions as sources of antioxidant and selective anticancer compounds."
Journal • Melanoma • Oncology • Solid Tumor
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Ana-Maria Vlase; Aureliana Gabriela Antal; Delia Muntean; Diana-Simona Tchiakpe-Antal; Larisa Bihoi-R?doi; Laurian Vlase
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